GenProtEC Query: b4136

MultiModular Protein
dipZ
b4136
ECK4130
fused thiol:disulfide interchange protein
Gene Synonyms
htrI;dsbD;dipZ;cycZ;cutA2;
Gene Products of Modules
Module Location Function Gene Type E.C Number(s)
b4136_1 N-terminal thiol:disulfide interchange protein, cytochrome c-type biogenesis, electron carrier, N-terminal interacts with and activates DsbC Enzyme None
b4136_2 C-terminal thiol:disulfide interchange protein, cytochrome c-type biogenesis, electron carrier, N-terminal interacts with and activates DsbC Enzyme 1.8.1.8
Structural Domain Assignments ( Superfamily )
Module (click for details) Superfamily ID Domain Annotation
b4136_1 74863 Thiol:disulfide interchange protein DsbD, N-terminal domain (DsbD-alpha)
b4136_2 52833 Thioredoxin-like
Method of Assignment
Module Basis of Assignment
b4136_1 Experimental
b4136_2 Experimental
Literature Reference(s)
Sl.No Author(s) Journal Title Volume Year Pages REFID
1 Chung, J., Chen, T., and Missiakas, D. Mol.Microbiol Transfer of electrons across the cytoplasmic membrane by DsbD, a membrane protein involved in thiol-disulphide exchange and protein folding in the bacterial periplasm 35 2000 1099 - 1109 10712691
2 Krupp, R., Chan, C., and Missiakas, D. J.Biol.Chem. DsbD-catalyzed transport of electrons across the membrane of Escherichia coli 276 2001 3696 - 3701 11085993
3 Goldstone, D., Haebel, P. W., Katzen, F., Bader, M. W., Bardwell, J. C., Beckwith, J., and Metcalf, P. Proceedings.of the.National.Academy.of Sciences.of DsbC activation by the N-terminal domain of DsbD 98 2001 9551 - 9556 11493705
4 Rietsch, A., Belin, D., Martin, N., and Beckwith, J. Proc.Natl.Acad.Sci.U.S.A. An in vivo pathway for disulfide bond isomerization in Escherichia coli 93 1996 13048 - 13053 8917542
Physiological Role(s) of Protein Module(s)
b4136_1 : Metabolism --> Macromolecules (cellular constituent) biosynthesis --> Large molecule carriers --> Cytochromes
b4136_1 : Cell structure --> Membrane
b4136_1 : Location of gene products --> Inner membrane
b4136_2 : Metabolism --> Macromolecules (cellular constituent) biosynthesis --> Large molecule carriers --> Cytochromes
b4136_2 : Metabolism --> Metabolism of other compounds --> Sulfur metabolism
b4136_2 : Cell structure --> Membrane
b4136_2 : Location of gene products --> Inner membrane
Links to related Databases
GenBank (GI) SwissProt EcoGene EchoBASE
1790578 P36655 EG12178 EB2095
Sequence Similar Group(s) Click to see members
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