metH
b4019
ECK4011 |
homocysteine-N5-methyltet
rahydrofolate
transmethylase,
B12-dependent
|
| |
| Gene Synonyms |
| metH |
| Gene Product |
| Length |
Gene Type |
E.C Number(s) |
| 1227 |
Enzyme |
2.1.1.13 |
| Structural Domain Assignments (
Superfamily ) |
| Module (click for details) |
Superfamily ID |
Domain Annotation |
|
b4019 |
82282 |
Betaine-homocysteine S-methyltransferase |
|
b4019 |
51717 |
Dihydropteroate synthetase-like |
|
b4019 |
47644 |
Methionine synthase domain |
|
b4019 |
52242 |
Cobalamin (vitamin B12)-binding domain |
|
b4019 |
56507 |
Methionine synthase activation domain-like |
| Method of Assignment |
| Experimental |
| Literature Reference(s) |
| Sl.No |
Author(s) |
Journal |
Title |
Volume |
Year |
Pages |
REFID |
| 1 |
Bandarian, V., Pattridge, K. A., Lennon, B. W., Huddler, D. P., Matthews, R. G., and Ludwig, M. L. |
Nature Structural.Biology. |
Domain alternation switches B(12)-dependent methionine synthase to the activation conformation |
9 |
2002 |
53 - 56 |
11731805
|
| 2 |
Banerjee, R. V., Johnston, N. L., Sobeski, J. K., Datta, P., and Matthews, R. G. |
J.Biol.Chem. |
Cloning and sequence analysis of the Escherichia coli metH gene encoding cobalamin-dependent methionine synthase and isolation of a tryptic fragment containing the cobalamin-binding domain |
264 |
1989 |
13888 - 13895 |
2668277
|
| 3 |
Blattner, F. R., Burland, V., Plunkett, G., Sofia, H. J., and Daniels, D. L. |
Nucleic Acids Res. |
Analysis of the Escherichia coli genome. IV. DNA sequence of the region from 89.2 to 92.8 minutes |
21 |
1993 |
5408 - 5417 |
8346018
|
| Physiological Role(s) |
Metabolism --> Building block biosynthesis --> Amino acids --> Methionine
Metabolism --> Building block biosynthesis --> Cofactor, small molecule carrier --> Cobalamin (Vitamin B12)
Metabolism --> Central intermediary metabolism --> Formyl-tetrahydrofolate biosynthesis
| Metabolism --> Central intermediary metabolism --> S-adenosyl methionine biosynthesis |
| Links to related Databases |
| GenBank (GI) |
SwissProt |
EcoGene |
EchoBASE |
|
1790450 |
P13009 |
EG10587 |
EB0582 |
| |
| Sequence Similar Group(s) Click to see members |
| No Group Assignment
|
|
| |