adhE
b1241
ECK1235 |
fused acetaldehyde-CoA
dehydrogenase -!-
iron-dependent alcohol
dehydrogenase, NAD -!-
pyruvate-formate lyase
deactivase
|
| |
| Gene Synonyms |
| ana;adhE;adhC; |
| Gene Products of Modules |
| Module |
Location |
Function |
Gene Type |
E.C Number(s) |
| b1241_1 |
N-terminal |
acetaldehyde-CoA dehydrogenase, NAD-dependent |
Enzyme |
1.2.1.10 |
| b1241_2 |
C-terminal |
iron-dependent alcohol dehydrogenase, NAD |
Enzyme |
1.1.1.1 |
| Structural Domain Assignments (
Superfamily ) |
| Module (click for details) |
Superfamily ID |
Domain Annotation |
|
b1241_1 |
53720 |
ALDH-like |
|
b1241_2 |
56796 |
Dehydroquinate synthase-like |
| Method of Assignment |
| Module |
Basis of Assignment |
| b1241_1 |
Experimental
|
| b1241_2 |
Experimental
|
| Literature Reference(s) |
| Sl.No |
Author(s) |
Journal |
Title |
Volume |
Year |
Pages |
REFID |
| 1 |
Echave, P., Tamarit, J., Cabiscol, E., and Ros, J. |
J.Biol.Chem. |
Novel antioxidant role of alcohol dehydrogenase E from Escherichia coli |
32 |
2003 |
30193 - 30198 |
12783863
|
| 2 |
Nnyepi, M. R., Peng, Y., and Broderick, J. B. |
Arch.Biochem.Biophys. |
Inactivation of E. coli pyruvate formate-lyase: Role of AdhE and small molecules |
|
2007 |
0 - 0 |
17280641
|
| 3 |
Gupta, S. and Clark, D. P. |
J.Bacteriol. |
Escherichia coli derivatives lacking both alcohol dehydrogenase and phosphotransacetylase grow anaerobically by lactate fermentation |
171 |
1989 |
3650 - 3655 |
2661531
|
| 4 |
Kessler, D., Leibrecht, I., and Knappe, J. |
FEBS Lett. |
Pyruvate-formate-lyase-deactivase and acetyl-CoA reductase activities of Escherichia coli reside on a polymeric protein particle encoded by adhE |
281 |
1991 |
59 - 63 |
2015910
|
| 5 |
Rudolph, F. B., Purich, D. L., and Fromm, H. J. |
J.Biol.Chem. |
Coenzyme A-linked aldehyde dehydrogenase from Escherichia coli. I. Partial purification, properties, and kinetic studies of the enzyme |
243 |
1968 |
5539 - 5545 |
4301680
|
| Physiological Role(s) of Protein Module(s) |
b1241_1 : Metabolism --> Carbon compound utilization --> Others --> Ethanol degradation
b1241_1 : Metabolism --> Energy metabolism (carbon) --> Fermentation
| b1241_1 : Cell processes --> Adaptation to stress --> Other stresses (mechanical, nutritional, oxidative) |
b1241_2 : Metabolism --> Carbon compound utilization --> Others --> Ethanol degradation
b1241_2 : Metabolism --> Energy metabolism (carbon) --> Fermentation
| b1241_2 : Cell processes --> Adaptation to stress --> Other stresses (mechanical, nutritional, oxidative) |
| Links to related Databases |
| GenBank (GI) |
SwissProt |
EcoGene |
EchoBASE |
|
1787493 |
P17547 |
EG10031 |
EB0030 |
| |
| Sequence Similar Group(s) Click to see members |
|
acetaldehyde-CoA dehydrogenase |
|
iron-dependent alcohol dehydrogenase |
| |
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