Multimodular E. coli Proteins
A modular unit is a protein element of at least 83 amino acids that has an independent biological function. Most E. coli proteins contain one module. Proteins encoded by a gene that has undergone a gene fusion event contain two or more modules.
The bnumber extension indicate the location of the module in the protein


Module Location Function E.C Number
b0002_1 N-terminal aspartokinase I, threonine sensitive 2.7.2.4
b0002_2 C-terminal homoserine dehydrogenase I, threonine sensitive 1.1.1.3
b0067_1 N-terminal thiamin transport protein (ABC superfamily, membrane) None
b0067_2 C-terminal thiamin transport protein (ABC superfamily, membrane) None
b0149_1 N-terminal membrane module of bifunctional penicillin-binding protein 1b None
b0149_2 Middle glycosyl transferase of penicillin-binding protein 1b 2.4.1.129
b0149_3 C-terminal transpeptidase of penicillin-binding protein 1b 3.4.-.-
b0153_1 N-terminal hydroxamate-dependent iron transport protein (ABC superfamily, membrane) None
b0153_2 C-terminal hydroxamate-dependent iron transport protein (ABC superfamily, membrane) None
b0414_1 N-terminal diaminohydroxyphosphoribosylaminopyrimidine deaminase 3.5.4.26
b0414_2 C-terminal 5-amino-6-(5-phosphoribosylamino) uracil reductase 1.1.1.193
b0448_1 N-terminal predicted transport protein, multidrug resistance-like (ABC superfamily, membrane) None
b0448_2 C-terminal predicted transport protein, multidrug resistance-like (ABC superfamily, atp_bind) None
b0449_1 N-terminal predicted transport protein, multidrug resistance-like (ABC superfamily, membrane) None
b0449_2 C-terminal predicted transport protein, multidrug resistance-like (ABC superfamily, atp_bind) None
b0465_1 N-terminal unknown function module of mechanosensitive channel None
b0465_2 C-terminal mechanosensitive channel (MscS family) None
b0679_1 N-terminal PTS family enzyme IIC, N-acetylglucosamine-specific 2.7.1.69
b0679_2 Middle PTS family enzyme IIB, N-acetylglucosamine-specific 2.7.1.69
b0679_3 C-terminal PTS family enzyme IIA, N-acetylglucosamine-specific 2.7.1.69
b0695_1 N-terminal membrane signal input domain of sensory histidine kinase in two-component regulatory system wtih KdpE, regulation of potassium translocation, stabolized interaction with KdpE None
b0695_2 C-terminal cytoplasmic transmittor domain of sensory histidine kinase in two-component regulatory system wtih KdpE, regulation of potassium translocation None
b0731_1 N-terminal PTS family enzyme IIA, induction of ompC, 2-O-alpha-mannosyl-D-glycerate specific 2.7.1.69
b0731_2 Middle PTS family enzyme IIB, induction of ompC, 2-O-alpha-mannosyl-D-glycerate specific 2.7.1.69
b0731_3 C-terminal PTS family enzyme IIC, induction of ompC, 2-O-alpha-mannosyl-D-glycerate specific 2.7.1.69
b0760_1 N-terminal molybdenum transport protein (ABC superfamily, atp_bind) None
b0760_2 C-terminal molybdenum transport protein (ABC superfamily, atp_bind) None
b0794_1 N-terminal predicted transport protein (ABC superfamily, atp_bind) None
b0794_2 C-terminal predicted transport protein (ABC superfamily, atp_bind) None
b0820_1 N-terminal predicted transport protein (ABC superfamily, atp_bind) None
b0820_2 C-terminal predicted transport protein (ABC superfamily, atp_bind) None
b0829_1 N-terminal glutathione transporter (ABC superfamily, atp_bind) None
b0829_2 C-terminal glutathione transporter (ABC superfamily, atp_bind) None
b0879_1 N-terminal macrolide transport protein (ABC superfamily, atp_bind) None
b0879_2 C-terminal macrolide transport protein (ABC superfamily, membrane) None
b0886_1 N-terminal cysteine transport (export) protein (ABC superfamily, membrane) None
b0886_2 C-terminal cysteine transport (export) protein (ABC superfamily, atp_bind) None
b0887_1 N-terminal cysteine transport (export) protein (ABC superfamily, membrane) None
b0887_2 C-terminal cysteine transport (export) protein (ABC superfamily, atp_bind) None
b0914_1 N-terminal lipid transport protein, flippase (ABC superfamily, membrane) None
b0914_2 C-terminal lipid transport protein, flippase (ABC superfamily, atp_bind) None
b0924_1 N-terminal predicted nucleotide hydrolase module of kinesin-like cell division protein None
b0924_2 Middle unknown function module of kinesin-like cell division protein None
b0924_3 C-terminal unknown function module of kinesin-like cell division protein None
b0949_1 N-terminal predicted transport protein (ABC superfamily, atp_bind) None
b0949_2 C-terminal predicted transport protein (ABC superfamily, atp_bind) None
b0993_1 N-terminal histidine kinase of hybrid sensory kinase in two-component regulatory system with TorR, regulates TMAO reductase regulatory system I, senses TMAO None
b0993_2 C-terminal response regulator of hybrid sensory kinase in two-component regulatory system with TorR, regulates TMAO reductase regulatory system I, senses TMAO None
b1014_1 N-terminal bifunctional: transcriptional repressor of proline utilization (N-terminal); proline dehydrogenase, FAD-binding (C-terminal) 1.5.99.8
b1014_2 C-terminal pyrroline-5-carboxylate dehydrogenase, NAD-dependent 1.5.1.12
b1084_1 N-terminal endoribonuclease module of RNase E, rRNA processing and mRNA degradation 3.1.4.-
b1084_2 Middle RNA binding module of RNase E 3.1.4.-
b1084_3 C-terminal RNA degradosome binding module of RNase E 3.1.4.-
b1101_1 N-terminal PTS family enzyme IIC, glucose-specific 2.7.1.69
b1101_2 C-terminal PTS family enzyme IIB, glucose-specific 2.7.1.69
b1198_1 N-terminal predicted PTS family HPr components None
b1198_2 C-terminal predicted PTS family enzyme I None
b1241_1 N-terminal acetaldehyde-CoA dehydrogenase, NAD-dependent 1.2.1.10
b1241_2 C-terminal iron-dependent alcohol dehydrogenase, NAD 1.1.1.1
b1262_1 N-terminal indole-3-glycerolphosphate synthetase 4.1.1.48
b1262_2 C-terminal N-(5-phosphoribosyl)anthranilate isomerase 5.3.1.24
b1263_1 N-terminal glutamine amidotransferase 4.1.3.27
b1263_2 C-terminal anthranilate phosphoribosyltransferase 4.1.3.27
2.4.2.18
4.1.3.27
b1378_1 N-terminal unknown function module of predicted pyruvate-flavodoxin oxidoreductase None
b1378_2 Middle unknown function module of predicted pyruvate-flavodoxin oxidoreductase None
b1378_3 C-terminal Fe-S binding module of predicted pyruvate-flavodoxin oxidoreductase None
b1387_1 N-terminal aldehyde dehydrogenase in phenylacetate metabolism None
b1387_2 C-terminal enoyl CoA dehydtratase None
b1439_1 N-terminal predicted transcriptional regulator (GntR family) None
b1439_2 C-terminal predicted aminotransferase None
b1496_1 N-terminal predicted transport protein (ABC superfamily, membrane) None
b1496_2 C-terminal predicted transport protein (ABC superfamily, atp_bind) None
b1513_1 N-terminal predicted sugar transport protein (ABC superfamily, atp_bind) None
b1513_2 C-terminal predicted sugar transport protein (ABC superfamily, atp_bind) None
b1621_1 N-terminal PTS family enzyme IIC, maltose/glucose-specific 2.7.1.69
b1621_2 C-terminal PTS family enzyme IIB, maltose/glucose-specific 2.7.1.69
b1629_1 N-terminal Fe-S binding module of predicted electron transport protein None
b1629_2 C-terminal unknown membrane module of predicted electron transport protein None
b1694_1 N-terminal predicted acetyl-CoA:acetoacetyl-CoA transferase, alpha subunit None
b1694_2 C-terminal predicted acetyl-CoA:acetoacetyl-CoA transferase, beta subunit None
b1755_1 N-terminal predicted transport protein (ABC superfamily, membrane) None
b1755_2 C-terminal predicted transport protein (ABC superfamily, membrane) None
b1816_1 N-terminal predicted transmembrane protein None
b1816_2 C-terminal unknown function module of predicted transmembrane protein None
b1817_1 N-terminal PTS family enzyme IIA, mannose-specific 2.7.1.69
b1817_2 C-terminal PTS family enzyme IIB, mannose-specific 2.7.1.69
b1883_1 N-terminal response regulator of regulatory protein in two-component regulatory system with CheA, regulates chemotactic response None
b1883_2 C-terminal methylesterase of regulatory protein in two-component regulatory system with CheA, regulates chemotactic response 3.1.1.61
b1888_1 N-terminal histidine kinase module of sensory histidine kinase in two-component regulatory system with CheB and CheY None
b1888_2 C-terminal binding module of chemotactic sensory histidine kinase in two-component regulatory system with CheB and CheY None
b1900_1 N-terminal high-affinity L-arabinose transport protein (ABC superfamily, atp_bind) None
b1900_2 C-terminal high-affinity L-arabinose transport protein (ABC superfamily, atp_bind) None
b2022_1 N-terminal histidinol-phosphatase 3.1.3.15
b2022_2 C-terminal imidazoleglycerol-phosphate dehydratase 4.2.1.19
b2026_1 N-terminal phosphoribosyl-AMP cyclohydrolase 3.5.4.19
b2026_2 C-terminal phosphoribosyl-ATP pyrophosphatase 3.6.1.31
b2063_1 N-terminal predicted transmembrane protein None
b2063_2 C-terminal predicted transmembrane protein None
b2149_1 N-terminal galactose (methyl-galactoside) transport protein (ABC superfamily, atp_bind) None
b2149_2 C-terminal galactose (methyl-galactoside) transport protein (ABC superfamily, atp_bind) None
b2167_1 N-terminal PTS family enzyme IIB'B, fructose-specific 2.7.1.69
b2167_2 C-terminal PTS family enzyme IIC, fructose-specific 2.7.1.69
b2169_1 N-terminal PTS family enzyme IIA, fructose-specific 2.7.1.69
b2169_2 C-terminal PTS family enzyme FPr, fructose-specific None
b2180_1 N-terminal predicted oligopeptide transport protein (ABC superfamily, atp_bind) None
b2180_2 C-terminal predicted oligopeptide transport protein (ABC superfamily, atp_bind) None
b2211_1 N-terminal microcin transport proteins (ABC superfamily, membrane) None
b2211_2 C-terminal microcin transport proteins (ABC superfamily, atp_bind) None
b2213_1 N-terminal transcriptional regulator of DNA repair None
b2213_2 C-terminal O6-methylguanine-DNA methyltransferase 2.1.1.63
b2218_1 N-terminal histidine kinase of hybrid sensory kinase in two-component regulatory system with RcsB and YojN, regulates capsule biosynthesis, cell division genes, OsmC expression, flhDC operon None
b2218_2 C-terminal response regulator of hybrid sensory kinase in two-component regulatory system with RcsB and YojN, regulates capsule biosynthesis, cell division genes, OsmC expression, flhDC operon None
b2220_1 N-terminal response regulator in two-component regulatory system with AtoS, regulates acetoacetate metabolism None
b2220_2 C-terminal sigma54 interaction module of response regulator in two-component regulatory system with AtoS, regulates acetoacetate metabolism (EBP family) None
b2255_1 N-terminal UDP-4-amino-4-deoxy-1-arabinose formyl transferase, N-10-formyltetrahydrofolate dependent 2.1.2.-
b2255_2 C-terminal UDPglucuronate decarboxylase 4.1.1.35
b2324_1 N-terminal methyltransferase of 5-methylaminomethyl-2-thiouridine forming enzyme 2.1.1.-
b2324_2 C-terminal FAD-dependent demodification enzyme5-methylaminomethyl-2-thiouridine forming enzyme None
b2341_1 N-terminal multifunctional enoyl-CoA hydratase;epimerase;isomerase of anaerobic fatty acid oxidation complex protein None
4.2.1.17
5.1.2.3
5.3.3.8
b2341_2 C-terminal 3-hydroxyacyl-CoA dehydrogenase of anaerobic fatty acid oxidation complex protein 1.1.1.35
b2370_1 N-terminal histidine kinase of hybrid sensory kinase in two-component regulatory system with EvgA, regulates multidrug resistance None
b2370_2 C-terminal response regulator of hybrid sensory histidine kinase in two-component regulatory system with EvgA, regulates multidrug resistance None
b2383_1 N-terminal predicted PTS family Hpr component None
b2383_2 Middle predicted PTS family enzyme I component 2.7.3.9
b2383_3 C-terminal predicted PTS family enzyme IIA component 2.7.1.69
b2463_1 N-terminal predicted malic enzyme, NAD (malate oxidative decarboxylase) None
b2463_2 C-terminal predicted phosphotransacetylase None
b2468_1 N-terminal Fe-S binding module of predicted oxidoreductase None
b2468_2 C-terminal NAD/FAD-binding module of predicted oxidoreductase subunit similar to GltD None
b2519_1 N-terminal transglycosylase of penicillin-binding protein 1c 2.4.1.-
b2519_2 C-terminal transpeptidase of penicillin-binding protein 1c 3.4.-
b2547_1 N-terminal predicted sugar transport protein (ABC superfamily, atp_bind) None
b2547_2 C-terminal predicted sugar transport protein (ABC superfamily, atp_bind) None
b2552_1 N-terminal nitric oxide dioxygenase 1.14.12.17
b2552_2 C-terminal dihydropteridine reductase 2 1.6.99.7
b2554_1 N-terminal predicted response regulator in two-component regulatory system None
b2554_2 C-terminal predicted sigma54 interaction module of response regulator in two-component regulatory system (EBP family) None
b2584_1 N-terminal NAD(P)-binding module of predicted acyl-CoA synthetase None
b2584_2 C-terminal ATP-binding module of predicted acyl-CoA synthetase None
b2599_1 N-terminal chorismate mutase P 5.4.99.5
b2599_2 C-terminal prephenate dehydratase 4.2.1.51
b2600_1 N-terminal chorismate mutase T 5.4.99.5
b2600_2 C-terminal prephenate dehydrogenase 1.3.1.12
b2786_1 N-terminal histidine kinase of hybrid sensory histidine kinase in two-component regulatory system with UvrY None
b2786_2 C-terminal response regulator of hybrid sensory histidine kinase in two-component regulatory system with UvrY None
b2818_1 N-terminal acetylglutamate kinase homolog (inactive) None
b2818_2 C-terminal N-alpha-acetylglutamate synthase (amino acid acetyltransferase) 2.3.1.1
b2829_1 N-terminal GAF domain containing module of PTS family protein None
b2829_2 C-terminal PTS family enzyme I 2.7.3.9
b2836_1 N-terminal 2-acylglycerophospho-ethanolamine acyl transferase 2.3.1.40
b2836_2 C-terminal acyl-acyl carrier protein synthetase 6.2.1.20
b2881_1 N-terminal molybdopterin-binding module of predicted selenate reductase None
b2881_2 C-terminal Fe-S binding module of predicted selenate reductase None
b2887_1 N-terminal Fe-S binding module of predicted oxidoreductase None
b2887_2 C-terminal nucleotide-binding module of predicted oxidoreductase, FeS None
b2988_1 N-terminal glutathionylspermidine amidase 3.5.1.78
b2988_2 C-terminal glutathionylspermidine synthetase 6.3.1.8
b3052_1 N-terminal kinase module of ADP-L-glycero-D-manno-heptose synthase 2.7.1.-
b3052_2 C-terminal sugar nucleotide transferase of ADP-L-glycero-D-manno-heptose synthase 2.7.7.-
b3053_1 N-terminal deadenylylase for glutamine synthetase, regulates P-II (GlnB) and GlnK 2.7.7.42
b3053_2 C-terminal adenylylase for glutamine synthetase, regulates P-II (GlnB) and GlnK 2.7.7.42
b3056_1 N-terminal tRNA nucleotidyl transferase 2.7.7.42
2.7.7.25
3.1.4.17
b3056_2 C-terminal 2'3'-cyclic phosphodiesterase, 2'nucleotidase, and phosphatase 3.1.4.17
b3072_1 N-terminal sensory module of aerotaxis sensor receptor, senses cellular redox state or proton motive force None
b3072_2 C-terminal methyl accepting chemotaxis module of aerotaxis sensor receptor, senses cellular redox state or proton motive force None
b3168_1 N-terminal membrane module of protein chain initiation factor IF-2 None
b3168_2 C-terminal protein chain initiation factor IF-2 None
b3210_1 N-terminal sensory kinase of hybrid sensory histidine kinase in two-component regulatory system with ArcA, regulates respiration and fermentation, senses oxidized quinones None
b3210_2 C-terminal response regulator of hybrid sensory histidine kinase in two-component regulatory system with ArcA, regulates respiration and fermentation, senses oxidized quinones None
b3352_1 N-terminal predicted transport protein (ABC superfamily, atp_bind) None
b3352_2 C-terminal predicted transport protein (ABC superfamily, atp_bind) None
b3368_1 N-terminal bifunctional: 1,3-dimethyluroporphyriongen III dehydrogenase; siroheme ferrochelatase of siroheme synthase None
1.-.-.-
4.99.1.-
b3368_2 C-terminal uroporphyrinogen methyltransferase of siroheme synthase 2.1.1.107
b3396_1 N-terminal transglycosylase of penicillin-binding protein 1a 2.4.1.-
b3396_2 C-terminal transpeptidase of bifunctional penicillin-binding protein 1a 3.4.-
b3409_1 N-terminal GTP-binding module of ferrous iron transport protein B (FeoB family) None
b3409_2 C-terminal membrane module of ferrous iron transport protein B (FeoB family) None
b3418_1 N-terminal unknown function module of transcriptional activator, possible MalY interaction site None
b3418_2 C-terminal transcriptional activator of maltose utilization (LysR familiy) None
b3464_1 N-terminal membrane binding module of cell division protein None
b3464_2 C-terminal unknown function module of cell division protein None
b3486_1 N-terminal ATP-binding module of ribosome-associated ATPase None
b3486_2 Middle ATP-binding module of ribosome-associated ATPase None
b3486_3 C-terminal predicted membrane protein of ribosome-associated ATPase None
b3567_1 N-terminal D-xylose transport protein (ABC superfamily, atp_bind) None
b3567_2 C-terminal D-xylose transport protein (ABC superfamily, atp_bind) None
b3599_1 N-terminal PTS family enzyme IICB, mannitol-specific 2.7.1.69
b3599_2 C-terminal PTS family enzyme IIA, mannitol-specific 2.7.1.69
b3639_1 N-terminal 4'-phosphopantothenoylcysteine decarboxylase 4.1.1.36
b3639_2 C-terminal phosphopantothenoylcysteine synthetase, FMN-binding 6.3.2.5
b3722_1 N-terminal PTS family enzyme IIBC, beta-glucoside-specific, cryptic 2.7.1.69
b3722_2 C-terminal PTS family enzyme IIA, beta-glucoside-specific, cryptic 2.7.1.69
b3730_1 N-terminal N-acetyl glucosamine-1-phosphate uridyltransferase 2.7.7.23
b3730_2 C-terminal glucosamine-1-phosphate acetyltransferase 2.3.1.157
b3746_1 N-terminal fused AAA+ ATPase None
b3746_2 C-terminal fused AAA+ ATPase None
b3749_1 N-terminal high-affinity D-ribose transport protein (ABC superfamily, atp_bind) None
b3749_2 C-terminal high-affinity D-ribose transport protein (ABC superfamily, atp_bind) None
b3846_1 N-terminal multifunctional 3-hydroxybutyryl-CoA epimerase, delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase, enoyl-CoA hydratase None
4.2.1.17
5.1.2.3
5.3.3.8
b3846_2 C-terminal 3-hydroxyacyl-CoA dehydrogenase 1.1.1.35
b3863_1 N-terminal 5'->3' exonuclease of DNA polymerase I None
b3863_2 C-terminal bifunctional: 3'->5' exonuclease; 3'->5' polymerase of DNA polymerase I None
b3868_1 N-terminal response regulator in two-component regulatory system with GlnL, nitrogen regulation None
b3868_2 C-terminal sigma54 interaction module of response regulator in two-component regulatory system with GlnL, nitrogen regulation (EBP family) None
b3899_1 N-terminal predicted PTS family enzyme IIB, fructose-specific 2.7.1.69
b3899_2 C-terminal predicted PTS family enzyme IIC, fructose-specific 2.7.1.69
b3940_1 N-terminal aspartokinase II, methionine sensitive 2.7.2.4
b3940_2 C-terminal homoserine dehydrogenase II, methionine sensitive 1.1.1.3
b3947_1 N-terminal predicted bifunctional PTS family Hpr; enzyme I None
b3947_2 C-terminal predicted PTS family enzyme IIA None
b4004_1 N-terminal response regulator in two-component reguatory system with ZraS, regulates zraP expression None
b4004_2 C-terminal sigma54 interaction module of response regulator in two-component reguatory system with ZraS, regulates zraP expression (EBP family) None
b4006_1 N-terminal IMP cyclohydrolase 3.5.4.10
b4006_2 C-terminal phosphoribosylaminoimidazolecarboxamide formyltransferase 2.1.2.3
b4035_1 N-terminal maltose transport protein (ABC superfamily, atp_bind) None
b4035_2 C-terminal regulatory module, repression of mal operon and regulatory interaction with MalT and MalX None
b4087_1 N-terminal allose transport protein (ABC superfamily, atp_bind) None
b4087_2 C-terminal allose transport protein (ABC superfamily, atp_bind) None
b4136_1 N-terminal thiol:disulfide interchange protein, cytochrome c-type biogenesis, electron carrier, N-terminal interacts with and activates DsbC None
b4136_2 C-terminal thiol:disulfide interchange protein, cytochrome c-type biogenesis, electron carrier, N-terminal interacts with and activates DsbC 1.8.1.8
b4340_1 N-terminal predicted regulator None
b4340_2 C-terminal predicted aminotransferase None
b4391_1 N-terminal predicted transport protein (ABC superfamily, atp_bind) None
b4391_2 C-terminal predicted transport protein (ABC superfamily, atp_bind) None