Gen Prot EC Multimodular proteins in E. coli. August 28th, 2007 The bnumber extension indicates location of module in the gene. _1 = N-terminal _2 = C-terminal to _1 _3 = C-terminal to _2 bnum module module function EC no1 EC no2 EC no3 b0002 b0002_1 aspartokinase I, threonine sensitive 2.7.2.4 b0002 b0002_2 homoserine dehydrogenase I, threonine sensitive 1.1.1.3 b0067 b0067_1 thiamin transport protein (ABC superfamily, membrane) b0067 b0067_2 thiamin transport protein (ABC superfamily, membrane) b0149 b0149_1 membrane module of bifunctional penicillin-binding protein 1b b0149 b0149_2 glycosyl transferase of penicillin-binding protein 1b 2.4.1.129 b0149 b0149_3 transpeptidase of penicillin-binding protein 1b 3.4.-.- b0153 b0153_1 hydroxamate-dependent iron transport protein (ABC superfamily, membrane) b0153 b0153_2 hydroxamate-dependent iron transport protein (ABC superfamily, membrane) b0414 b0414_1 diaminohydroxyphosphoribosylaminopyrimidine deaminase 3.5.4.26 b0414 b0414_2 5-amino-6-(5-phosphoribosylamino) uracil reductase 1.1.1.193 b0448 b0448_1 predicted transport protein, multidrug resistance-like (ABC superfamily, membrane) b0448 b0448_2 predicted transport protein, multidrug resistance-like (ABC superfamily, atp_bind) b0449 b0449_1 predicted transport protein, multidrug resistance-like (ABC superfamily, membrane) b0449 b0449_2 predicted transport protein, multidrug resistance-like (ABC superfamily, atp_bind) b0465 b0465_1 unknown function module of mechanosensitive channel b0465 b0465_2 mechanosensitive channel (MscS family) b0679 b0679_1 PTS family enzyme IIC, N-acetylglucosamine-specific 2.7.1.69 b0679 b0679_2 PTS family enzyme IIB, N-acetylglucosamine-specific 2.7.1.69 b0679 b0679_3 PTS family enzyme IIA, N-acetylglucosamine-specific 2.7.1.69 b0695 b0695_1 membrane signal input domain of sensory histidine kinase in two-component regulatory system wtih KdpE, regulation of potassium translocation, stabolized interaction with KdpE b0695 b0695_2 cytoplasmic transmittor domain of sensory histidine kinase in two-component regulatory system wtih KdpE, regulation of potassium translocation b0731 b0731_1 PTS family enzyme IIA, induction of ompC, 2-O-alpha-mannosyl-D-glycerate specific 2.7.1.69 b0731 b0731_2 PTS family enzyme IIB, induction of ompC, 2-O-alpha-mannosyl-D-glycerate specific 2.7.1.69 b0731 b0731_3 PTS family enzyme IIC, induction of ompC, 2-O-alpha-mannosyl-D-glycerate specific 2.7.1.69 b0760 b0760_1 molybdenum transport protein (ABC superfamily, atp_bind) b0760 b0760_2 molybdenum transport protein (ABC superfamily, atp_bind) b0794 b0794_1 predicted transport protein (ABC superfamily, atp_bind) b0794 b0794_2 predicted transport protein (ABC superfamily, atp_bind) b0820 b0820_1 predicted transport protein (ABC superfamily, atp_bind) b0820 b0820_2 predicted transport protein (ABC superfamily, atp_bind) b0829 b0829_1 glutathione transporter (ABC superfamily, atp_bind) b0829 b0829_2 glutathione transporter (ABC superfamily, atp_bind) b0879 b0879_1 macrolide transport protein (ABC superfamily, atp_bind) b0879 b0879_2 macrolide transport protein (ABC superfamily, membrane) b0886 b0886_1 cysteine transport (export) protein (ABC superfamily, membrane) b0886 b0886_2 cysteine transport (export) protein (ABC superfamily, atp_bind) b0887 b0887_1 cysteine transport (export) protein (ABC superfamily, membrane) b0887 b0887_2 cysteine transport (export) protein (ABC superfamily, atp_bind) b0914 b0914_1 lipid transport protein, flippase (ABC superfamily, membrane) b0914 b0914_2 lipid transport protein, flippase (ABC superfamily, atp_bind) b0924 b0924_1 predicted nucleotide hydrolase module of kinesin-like cell division protein b0924 b0924_2 unknown function module of kinesin-like cell division protein b0924 b0924_3 unknown function module of kinesin-like cell division protein b0949 b0949_1 predicted transport protein (ABC superfamily, atp_bind) b0949 b0949_2 predicted transport protein (ABC superfamily, atp_bind) b0993 b0993_1 histidine kinase of hybrid sensory kinase in two-component regulatory system with TorR, regulates TMAO reductase regulatory system I, senses TMAO b0993 b0993_2 response regulator of hybrid sensory kinase in two-component regulatory system with TorR, regulates TMAO reductase regulatory system I, senses TMAO b1014 b1014_1 bifunctional: transcriptional repressor of proline utilization (N-terminal); proline dehydrogenase, FAD-binding (C-terminal) 1.5.99.8 b1014 b1014_2 pyrroline-5-carboxylate dehydrogenase, NAD-dependent 1.5.1.12 b1084 b1084_1 endoribonuclease module of RNase E, rRNA processing and mRNA degradation 3.1.4.- b1084 b1084_2 RNA binding module of RNase E 3.1.4.- b1084 b1084_3 RNA degradosome binding module of RNase E 3.1.4.- b1101 b1101_1 PTS family enzyme IIC, glucose-specific 2.7.1.69 b1101 b1101_2 PTS family enzyme IIB, glucose-specific 2.7.1.69 b1198 b1198_1 predicted PTS family HPr components b1198 b1198_2 predicted PTS family enzyme I b1241 b1241_1 acetaldehyde-CoA dehydrogenase, NAD-dependent 1.2.1.10 b1241 b1241_2 iron-dependent alcohol dehydrogenase, NAD 1.1.1.1 b1262 b1262_1 indole-3-glycerolphosphate synthetase 4.1.1.48 b1262 b1262_2 N-(5-phosphoribosyl)anthranilate isomerase 5.3.1.24 b1263 b1263_1 glutamine amidotransferase 4.1.3.27 b1263 b1263_2 anthranilate phosphoribosyltransferase 4.1.3.27 2.4.2.18 b1378 b1378_1 unknown function module of predicted pyruvate-flavodoxin oxidoreductase b1378 b1378_2 unknown function module of predicted pyruvate-flavodoxin oxidoreductase b1378 b1378_3 Fe-S binding module of predicted pyruvate-flavodoxin oxidoreductase b1387 b1387_1 aldehyde dehydrogenase in phenylacetate metabolism b1387 b1387_2 enoyl CoA dehydtratase b1439 b1439_1 predicted transcriptional regulator (GntR family) b1439 b1439_2 predicted aminotransferase b1496 b1496_1 predicted transport protein (ABC superfamily, membrane) b1496 b1496_2 predicted transport protein (ABC superfamily, atp_bind) b1513 b1513_1 predicted sugar transport protein (ABC superfamily, atp_bind) b1513 b1513_2 predicted sugar transport protein (ABC superfamily, atp_bind) b1621 b1621_1 PTS family enzyme IIC, maltose/glucose-specific 2.7.1.69 b1621 b1621_2 PTS family enzyme IIB, maltose/glucose-specific 2.7.1.69 b1629 b1629_1 Fe-S binding module of predicted electron transport protein b1629 b1629_2 unknown membrane module of predicted electron transport protein b1694 b1694_1 predicted acetyl-CoA:acetoacetyl-CoA transferase, alpha subunit b1694 b1694_2 predicted acetyl-CoA:acetoacetyl-CoA transferase, beta subunit b1755 b1755_1 predicted transport protein (ABC superfamily, membrane) b1755 b1755_2 predicted transport protein (ABC superfamily, membrane) b1816 b1816_1 predicted transmembrane protein b1816 b1816_2 unknown function module of predicted transmembrane protein b1817 b1817_1 PTS family enzyme IIA, mannose-specific 2.7.1.69 b1817 b1817_2 PTS family enzyme IIB, mannose-specific 2.7.1.69 b1883 b1883_1 response regulator of regulatory protein in two-component regulatory system with CheA, regulates chemotactic response b1883 b1883_2 methylesterase of regulatory protein in two-component regulatory system with CheA, regulates chemotactic response 3.1.1.61 b1888 b1888_1 histidine kinase module of sensory histidine kinase in two-component regulatory system with CheB and CheY b1888 b1888_2 binding module of chemotactic sensory histidine kinase in two-component regulatory system with CheB and CheY b1900 b1900_1 high-affinity L-arabinose transport protein (ABC superfamily, atp_bind) b1900 b1900_2 high-affinity L-arabinose transport protein (ABC superfamily, atp_bind) b2022 b2022_1 histidinol-phosphatase 3.1.3.15 b2022 b2022_2 imidazoleglycerol-phosphate dehydratase 4.2.1.19 b2026 b2026_1 phosphoribosyl-AMP cyclohydrolase 3.5.4.19 b2026 b2026_2 phosphoribosyl-ATP pyrophosphatase 3.6.1.31 b2063 b2063_1 predicted transmembrane protein b2063 b2063_2 predicted transmembrane protein b2149 b2149_1 galactose (methyl-galactoside) transport protein (ABC superfamily, atp_bind) b2149 b2149_2 galactose (methyl-galactoside) transport protein (ABC superfamily, atp_bind) b2167 b2167_1 PTS family enzyme IIB'B, fructose-specific 2.7.1.69 b2167 b2167_2 PTS family enzyme IIC, fructose-specific 2.7.1.69 b2169 b2169_1 PTS family enzyme IIA, fructose-specific 2.7.1.69 b2169 b2169_2 PTS family enzyme FPr, fructose-specific b2180 b2180_1 predicted oligopeptide transport protein (ABC superfamily, atp_bind) b2180 b2180_2 predicted oligopeptide transport protein (ABC superfamily, atp_bind) b2211 b2211_1 microcin transport proteins (ABC superfamily, membrane) b2211 b2211_2 microcin transport proteins (ABC superfamily, atp_bind) b2213 b2213_1 transcriptional regulator of DNA repair b2213 b2213_2 O6-methylguanine-DNA methyltransferase 2.1.1.63 b2218 b2218_1 histidine kinase of hybrid sensory kinase in two-component regulatory system with RcsB and YojN, regulates capsule biosynthesis, cell division genes, OsmC expression, flhDC operon b2218 b2218_2 response regulator of hybrid sensory kinase in two-component regulatory system with RcsB and YojN, regulates capsule biosynthesis, cell division genes, OsmC expression, flhDC operon b2220 b2220_1 response regulator in two-component regulatory system with AtoS, regulates acetoacetate metabolism b2220 b2220_2 sigma54 interaction module of response regulator in two-component regulatory system with AtoS, regulates acetoacetate metabolism (EBP family) b2255 b2255_1 UDP-4-amino-4-deoxy-1-arabinose formyl transferase, N-10-formyltetrahydrofolate dependent 2.1.2.- b2255 b2255_2 UDPglucuronate decarboxylase 4.1.1.35 b2324 b2324_1 methyltransferase of 5-methylaminomethyl-2-thiouridine forming enzyme 2.1.1.- b2324 b2324_2 FAD-dependent demodification enzyme5-methylaminomethyl-2-thiouridine forming enzyme b2341 b2341_1 multifunctional enoyl-CoA hydratase;epimerase;isomerase of anaerobic fatty acid oxidation complex protein 4.2.1.17 5.3.3.8 5.1.2.3 b2341 b2341_2 3-hydroxyacyl-CoA dehydrogenase of anaerobic fatty acid oxidation complex protein 1.1.1.35 b2370 b2370_1 histidine kinase of hybrid sensory kinase in two-component regulatory system with EvgA, regulates multidrug resistance b2370 b2370_2 response regulator of hybrid sensory histidine kinase in two-component regulatory system with EvgA, regulates multidrug resistance b2383 b2383_1 predicted PTS family Hpr component b2383 b2383_2 predicted PTS family enzyme I component 2.7.3.9 b2383 b2383_3 predicted PTS family enzyme IIA component 2.7.1.69 b2463 b2463_1 predicted malic enzyme, NAD (malate oxidative decarboxylase) b2463 b2463_2 predicted phosphotransacetylase b2468 b2468_1 Fe-S binding module of predicted oxidoreductase b2468 b2468_2 NAD/FAD-binding module of predicted oxidoreductase subunit similar to GltD b2519 b2519_1 transglycosylase of penicillin-binding protein 1c 2.4.1.- b2519 b2519_2 transpeptidase of penicillin-binding protein 1c 3.4.- b2547 b2547_1 predicted sugar transport protein (ABC superfamily, atp_bind) b2547 b2547_2 predicted sugar transport protein (ABC superfamily, atp_bind) b2552 b2552_1 nitric oxide dioxygenase 1.14.12.17 b2552 b2552_2 dihydropteridine reductase 2 1.6.99.7 b2554 b2554_1 predicted response regulator in two-component regulatory system b2554 b2554_2 predicted sigma54 interaction module of response regulator in two-component regulatory system (EBP family) b2584 b2584_1 NAD(P)-binding module of predicted acyl-CoA synthetase b2584 b2584_2 ATP-binding module of predicted acyl-CoA synthetase b2599 b2599_1 chorismate mutase P 5.4.99.5 b2599 b2599_2 prephenate dehydratase 4.2.1.51 b2600 b2600_1 chorismate mutase T 5.4.99.5 b2600 b2600_2 prephenate dehydrogenase 1.3.1.12 b2786 b2786_1 histidine kinase of hybrid sensory histidine kinase in two-component regulatory system with UvrY b2786 b2786_2 response regulator of hybrid sensory histidine kinase in two-component regulatory system with UvrY b2818 b2818_1 acetylglutamate kinase homolog (inactive) b2818 b2818_2 N-alpha-acetylglutamate synthase (amino acid acetyltransferase) 2.3.1.1 b2829 b2829_1 GAF domain containing module of PTS family protein b2829 b2829_2 PTS family enzyme I 2.7.3.9 b2836 b2836_1 2-acylglycerophospho-ethanolamine acyl transferase 2.3.1.40 b2836 b2836_2 acyl-acyl carrier protein synthetase 6.2.1.20 b2881 b2881_1 molybdopterin-binding module of predicted selenate reductase b2881 b2881_2 Fe-S binding module of predicted selenate reductase b2887 b2887_1 Fe-S binding module of predicted oxidoreductase b2887 b2887_2 nucleotide-binding module of predicted oxidoreductase, FeS b2988 b2988_1 glutathionylspermidine amidase 3.5.1.78 b2988 b2988_2 glutathionylspermidine synthetase 6.3.1.8 b3052 b3052_1 kinase module of ADP-L-glycero-D-manno-heptose synthase 2.7.1.- b3052 b3052_2 sugar nucleotide transferase of ADP-L-glycero-D-manno-heptose synthase 2.7.7.- b3053 b3053_1 deadenylylase for glutamine synthetase, regulates P-II (GlnB) and GlnK 2.7.7.42 b3053 b3053_2 adenylylase for glutamine synthetase, regulates P-II (GlnB) and GlnK 2.7.7.42 b3056 b3056_1 tRNA nucleotidyl transferase 2.7.7.25 3.1.4.17 b3056 b3056_2 2'3'-cyclic phosphodiesterase, 2'nucleotidase, and phosphatase 3.1.4.17 b3072 b3072_1 sensory module of aerotaxis sensor receptor, senses cellular redox state or proton motive force b3072 b3072_2 methyl accepting chemotaxis module of aerotaxis sensor receptor, senses cellular redox state or proton motive force b3168 b3168_1 membrane module of protein chain initiation factor IF-2 b3168 b3168_2 protein chain initiation factor IF-2 b3210 b3210_1 sensory kinase of hybrid sensory histidine kinase in two-component regulatory system with ArcA, regulates respiration and fermentation, senses oxidized quinones b3210 b3210_2 response regulator of hybrid sensory histidine kinase in two-component regulatory system with ArcA, regulates respiration and fermentation, senses oxidized quinones b3352 b3352_1 predicted transport protein (ABC superfamily, atp_bind) b3352 b3352_2 predicted transport protein (ABC superfamily, atp_bind) b3368 b3368_1 bifunctional: 1,3-dimethyluroporphyriongen III dehydrogenase; siroheme ferrochelatase of siroheme synthase 4.99.1.- 1.-.-.- b3368 b3368_2 uroporphyrinogen methyltransferase of siroheme synthase 2.1.1.107 b3396 b3396_1 transglycosylase of penicillin-binding protein 1a 2.4.1.- b3396 b3396_2 transpeptidase of bifunctional penicillin-binding protein 1a 3.4.- b3409 b3409_1 GTP-binding module of ferrous iron transport protein B (FeoB family) b3409 b3409_2 membrane module of ferrous iron transport protein B (FeoB family) b3418 b3418_1 unknown function module of transcriptional activator, possible MalY interaction site b3418 b3418_2 transcriptional activator of maltose utilization (LysR familiy) b3464 b3464_1 membrane binding module of cell division protein b3464 b3464_2 unknown function module of cell division protein b3486 b3486_1 ATP-binding module of ribosome-associated ATPase b3486 b3486_2 ATP-binding module of ribosome-associated ATPase b3486 b3486_3 predicted membrane protein of ribosome-associated ATPase b3567 b3567_1 D-xylose transport protein (ABC superfamily, atp_bind) b3567 b3567_2 D-xylose transport protein (ABC superfamily, atp_bind) b3599 b3599_1 PTS family enzyme IICB, mannitol-specific 2.7.1.69 b3599 b3599_2 PTS family enzyme IIA, mannitol-specific 2.7.1.69 b3639 b3639_1 4'-phosphopantothenoylcysteine decarboxylase 4.1.1.36 b3639 b3639_2 phosphopantothenoylcysteine synthetase, FMN-binding 6.3.2.5 b3722 b3722_1 PTS family enzyme IIBC, beta-glucoside-specific, cryptic 2.7.1.69 b3722 b3722_2 PTS family enzyme IIA, beta-glucoside-specific, cryptic 2.7.1.69 b3730 b3730_1 N-acetyl glucosamine-1-phosphate uridyltransferase 2.7.7.23 b3730 b3730_2 glucosamine-1-phosphate acetyltransferase 2.3.1.157 b3746 b3746_1 fused AAA+ ATPase b3746 b3746_2 fused AAA+ ATPase b3749 b3749_1 high-affinity D-ribose transport protein (ABC superfamily, atp_bind) b3749 b3749_2 high-affinity D-ribose transport protein (ABC superfamily, atp_bind) b3846 b3846_1 multifunctional 3-hydroxybutyryl-CoA epimerase, delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase, enoyl-CoA hydratase 4.2.1.17 5.3.3.8 5.1.2.3 b3846 b3846_2 3-hydroxyacyl-CoA dehydrogenase 1.1.1.35 b3863 b3863_1 5'->3' exonuclease of DNA polymerase I b3863 b3863_2 bifunctional: 3'->5' exonuclease; 3'->5' polymerase of DNA polymerase I b3868 b3868_1 response regulator in two-component regulatory system with GlnL, nitrogen regulation b3868 b3868_2 sigma54 interaction module of response regulator in two-component regulatory system with GlnL, nitrogen regulation (EBP family) b3899 b3899_1 predicted PTS family enzyme IIB, fructose-specific 2.7.1.69 b3899 b3899_2 predicted PTS family enzyme IIC, fructose-specific 2.7.1.69 b3940 b3940_1 aspartokinase II, methionine sensitive 2.7.2.4 b3940 b3940_2 homoserine dehydrogenase II, methionine sensitive 1.1.1.3 b3947 b3947_1 predicted bifunctional PTS family Hpr; enzyme I b3947 b3947_2 predicted PTS family enzyme IIA b4004 b4004_1 response regulator in two-component reguatory system with ZraS, regulates zraP expression b4004 b4004_2 sigma54 interaction module of response regulator in two-component reguatory system with ZraS, regulates zraP expression (EBP family) b4006 b4006_1 IMP cyclohydrolase 3.5.4.10 b4006 b4006_2 phosphoribosylaminoimidazolecarboxamide formyltransferase 2.1.2.3 b4035 b4035_1 maltose transport protein (ABC superfamily, atp_bind) b4035 b4035_2 regulatory module, repression of mal operon and regulatory interaction with MalT and MalX b4087 b4087_1 allose transport protein (ABC superfamily, atp_bind) b4087 b4087_2 allose transport protein (ABC superfamily, atp_bind) b4136 b4136_1 thiol:disulfide interchange protein, cytochrome c-type biogenesis, electron carrier, N-terminal interacts with and activates DsbC b4136 b4136_2 thiol:disulfide interchange protein, cytochrome c-type biogenesis, electron carrier, N-terminal interacts with and activates DsbC 1.8.1.8 b4340 b4340_1 predicted regulator b4340 b4340_2 predicted aminotransferase b4391 b4391_1 predicted transport protein (ABC superfamily, atp_bind) b4391 b4391_2 predicted transport protein (ABC superfamily, atp_bind)